Succinate-GPR-91 receptor signalling is responsible for nonalcoholic steatohepatitis-associated fibrosis: Effects of DHA supplementation.

Xue-Jing LiuLi XieKuo DuChang LiuNing-Ping ZhangChen-Jian GuYing WangManal F AbdelmalekWen-Yue DongXiu-Ping LiuChen NiuChen YangAnna Mae DiehlJian Wu

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

Succinate accumulation in steatotoic hepatocytes may result in HSC activation through GPR-91 receptor signalling in NASH progression, and the cross-talk between hepatocytes and HSC through GPR-91 signalling is most likely to be the molecular basis of fibrogenesis in NASH.

Keyphrases

fatty acid
liver injury
liver fibrosis