Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells.
Snehanshu ChowdhuryAnwesha KarDebaleena BhowmikAnupam GautamDebashree BasakIshita SarkarPuspendu GhoshDeborpita SarkarAlvina DekaParamita ChakrabortyAsima MukhopadhyayShikhar MehrotraSoumen BasakSandip PaulShilpak ChatterjeePublished in: Cancer research (2022)
IL12-mediated metabolic reprogramming increases intracellular acetyl CoA to promote the effector function of CD8+ T cells in nutrient-depleted tumor microenvironments, revealing strategies to potentiate the antitumor efficacy of T cells.