Effects of the nerve growth factor and its carrier protein on the inflammatory response from human monocytes.
Yann VerresAude BodinSarah ChevretTatiana VictoniThomas GicquelEmiliano BarretoVéronique Freund-MichelVincent LagentePublished in: Fundamental & clinical pharmacology (2024)
These data suggest that NGF is able to enhance monocyte inflammatory responses once cells are stimulated with another signal but is possibly not able to directly activate it. This could have implications for example in patients with bacterial infections, where NGF could worsen the local inflammation by over-activating immune cells.
Keyphrases
- growth factor
- inflammatory response
- endothelial cells
- induced apoptosis
- dendritic cells
- oxidative stress
- signaling pathway
- cell cycle arrest
- peripheral blood
- lipopolysaccharide induced
- electronic health record
- induced pluripotent stem cells
- pluripotent stem cells
- lps induced
- toll like receptor
- endoplasmic reticulum stress
- protein protein
- machine learning
- immune response
- cell proliferation
- peripheral nerve
- small molecule
- data analysis