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Severe Course of COVID-19 and Long-COVID-19 in Children: Difficulties in Diagnosis.

Elena S VasichkinaOlga KofeynikovaSvetlana FetisovaAnastasia Y StarshinovaElizaveta SheyanovaTatiana VershininaAnton RyzhkovAleksey SkripnikDaria AlekseevaElizaveta NechaevaAnzhela GlushkovaDmitry Anatolievich KudlayTatiana PervuninaAnna Starshinova
Published in: Life (Basel, Switzerland) (2023)
The question of COVID-19 and long-COVID-19 course in children remains unsolved. This infection in children, which is associated with COVID-19, can vary from asymptomatic to systemic damage of various systems. Multisystem inflammatory syndrome in children, associated with SARS-CoV-2 (MIS-C), is a serious condition in children and adolescents after experiencing COVID-19. Published data on MIS-C have indicated that the inflammation can be registered in the gastrointestinal tract (60-100%), as well as in cardiovascular (80%), nervous (29-58%), and respiratory (21-65%) systems. However, with the changing characteristics of SARS-CoV-2, the manifestations of COVID-19 and long-COVID-19 in children have also been changing. Currently, there is no clear understanding of the development of severe COVID-19 and MIS-C in children, especially after being exposed to patients with COVID-19. We presented two new clinical courses of multisystem inflammatory syndrome in children with severe multisystem damage after close contact to relatives with COVID-19 or long-COVID-19. Thus, high-risk children, who are positive for SARS-CoV-2 infection after contact with COVID-19 patients, should be clinically managed during the first few months. The identification of the disease complexity requires the involvement of neurologists, cardiologists, and other specialists.
Keyphrases
  • sars cov
  • coronavirus disease
  • respiratory syndrome coronavirus
  • young adults
  • oxidative stress
  • randomized controlled trial
  • case report
  • early onset