Effects of Pentoxifylline on Soluble Klotho Concentrations and Renal Tubular Cell Expression in Diabetic Kidney Disease.

Juan Francisco Navarro-GonzálezMaría Dolores Sánchez-NiñoJavier Donate-CorreaErnesto Martín-NúñezCarla FerriNayra Pérez-DelgadoJosé Luis GórrizAlberto Martínez-CastelaoAlberto OrtizCarmen Mora-Fernández

Published in: Diabetes care (2018)

Pentoxifylline increased Klotho levels in patients with diabetes with stage 3-4 CKD and prevented reduced Klotho expression in vitro. This beneficial effect may be related to anti-inflammatory and antialbuminuric activity.

Keyphrases

poor prognosis
anti inflammatory
chronic kidney disease
type diabetes
single cell
binding protein
long non coding rna
stem cells
wound healing