Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study.
Alastair J NoyceDemis A KiaGibran HemaniAude NicolasT Ryan PriceEduardo De Pablo-FernandezPhilip C HaycockPatrick A LewisThomas FoltynieGeorge Davey Smithnull nullAnette SchragAndrew J LeesJohn HardyAndrew SingletonMike A NallsNeil PearceDeborah A LawlorNicholas W WoodPublished in: PLoS medicine (2017)
In this large study using two-sample MR, we found that variants known to influence BMI had effects on PD in a manner consistent with higher BMI leading to lower risk of PD. The mechanism underlying this apparent protective effect warrants further study.