PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α.
Ryota ShizuKanako EzakiTakumi SatoAyaka SugawaraTakuomi HosakaTakamitsu SasakiKouichi YoshinariPublished in: Cells (2021)
The present results suggest that ligand-activated PXR suppresses PPARα-dependent gene expression by inhibiting PGC1α recruitment.