Distinct "Immunoallertypes" of Disease and High Frequencies of Sensitization in Non-Cystic Fibrosis Bronchiectasis.
Micheál Mac AogáinPei Yee TiewAlbert Yick Hou LimTeck Boon LowGan Liang TanTidi HassanThun How OngSze Lei PangZi Yang LeeXiao Wei GweeChristopher MartinusYang Yie SioSri Anusha MattaTan Ching OngYuen Seng TiongKang Ning WongSriram NarayananVeonice Bijin AuDamien MarlierHolly R KeirAugustine TeeJohn Arputhan AbisheganadenMariko Siyue KohDe Yun WangJohn E ConnollyFook Tim ChewJames D ChalmersSanjay Haresh ChotirmallPublished in: American journal of respiratory and critical care medicine (2020)
Allergic sensitization occurs at high frequency in patients with bronchiectasis recruited from different global centers. Improving endophenotyping of sensitized bronchiectasis, a clinically significant state, and a "treatable trait" permits therapeutic intervention in appropriate patients, and may allow improved stratification in future bronchiectasis research and clinical trials.
Keyphrases
- cystic fibrosis
- high frequency
- pseudomonas aeruginosa
- lung function
- clinical trial
- transcranial magnetic stimulation
- end stage renal disease
- randomized controlled trial
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- genome wide
- dna methylation
- phase ii
- study protocol
- genome wide association