HLA-DRB1*15:01 and the MERTK Gene Interact to Selectively Influence the Profile of MERTK-Expressing Monocytes in Both Health and MS.
Michele D BinderEze C NwokeEllen MorwitchChristopher M DwyerVivien LiAlexandre XavierRodney A LeaJeannette Lechner-ScottBruce V TaylorAnne-Louise PonsonbyTrevor J Kilpatricknull nullPublished in: Neurology(R) neuroimmunology & neuroinflammation (2023)
gene provides a molecular link between these loci and identifies a potential mechanism by which MERTK expression is influenced by DR15. This links DR15 haplotype to MS susceptibility beyond direct influence on antigen presentation and suggests the need for HLA-based stratification of approaches to MERTK as a therapeutic target.
Keyphrases
- genome wide
- mass spectrometry
- multiple sclerosis
- copy number
- ms ms
- dna methylation
- healthcare
- public health
- editorial comment
- poor prognosis
- mental health
- genome wide identification
- human health
- dendritic cells
- gene expression
- health information
- long non coding rna
- case report
- immune response
- transcription factor
- climate change
- genome wide association study