Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis.

Qi Li Yifan HongJing ChenXiazhu ZhouXiaomao TianYihang YuLianju ShenChunlan LongMiao CaiShengde WuGuanghui Wei

Published in: Cells (2022)

EMT and pyroptosis were involved in the development of SCI-induced bladder fibrosis via the HIF-1α pathway. Inhibition of the HIF-1α pathway may serve as a potential target to alleviate bladder fibrosis caused by SCI.

Keyphrases

spinal cord injury
epithelial mesenchymal transition
endothelial cells
nlrp inflammasome
high glucose
poor prognosis
urinary tract
liver fibrosis
drug induced
oxidative stress
climate change