Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury.
Philipp LassarénCaroline LindbladArvid FrostellKeri L H CarpenterMathew R GuilfoylePeter J A HutchinsonAdel HelmyEric Peter ThelinPublished in: Journal of neuroinflammation (2021)
Systemic inflammation, and infection in particular, alters cytokine levels with different patterns seen in brain and in blood. Cerebral inflammatory monitoring provides independent information from arterial and jugular samples, which both demonstrate similar information content. These findings could present potential new treatment options in severe TBI patients, but novel prospective trials are warranted to confirm these associations.
Keyphrases
- traumatic brain injury
- clinical trial
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- health information
- subarachnoid hemorrhage
- white matter
- cerebral ischemia
- oxidative stress
- randomized controlled trial
- multiple sclerosis
- healthcare
- brain injury
- phase ii
- ultrasound guided
- drug induced
- blood brain barrier
- double blind
- cerebral blood flow