Osteocyte Cellular Senescence.
Joshua N FarrJapneet KaurMadison L DoolittleSundeep KhoslaPublished in: Current osteoporosis reports (2021)
Numerous studies have established that senescent osteocytes accumulate in the bone microenvironment with aging in mice and in humans. Moreover, at least in mice, elimination of senescent cells results in attenuation of age-related bone loss. Osteocyte senescence also occurs in response to other cellular stressors, including radiotherapy, chemotherapy, and metabolic dysfunction, where it appears to mediate skeletal deterioration. Osteocyte senescence is linked to bone loss associated with aging and other conditions. Senescent osteocytes are potential therapeutic targets to alleviate skeletal dysfunction. Additional studies better defining the underlying mechanisms as well as translating these exciting findings from mouse models to humans are needed.
Keyphrases
- bone loss
- dna damage
- endothelial cells
- induced apoptosis
- oxidative stress
- high fat diet induced
- stress induced
- locally advanced
- mouse model
- case control
- early stage
- stem cells
- radiation therapy
- cell cycle arrest
- squamous cell carcinoma
- cell proliferation
- insulin resistance
- metabolic syndrome
- rectal cancer
- skeletal muscle