Incidental germline findings during molecular profiling of tumor tissues for precision oncology: molecular survey and methodological obstacles.

Alexandra LebedevaYulia ShaykhutdinovaDaria SeriakEkaterina IgnatovaEkaterina RozhavskayaDivyasphoorthi VardhanSofia ManickaMargarita SharovaTatiana GrigorevaAncha BaranovaVladislav MileykoMaxim Ivanov

Published in: Journal of translational medicine (2022)

Incidental findings of pathogenic germline variants are common in data from cancer patients referred for complex molecular profiling. We propose an algorithm for the management of patients with newly detected variants in genes associated with HCS.

Keyphrases

copy number
dna repair
single cell
machine learning
gene expression
single molecule
cross sectional
oxidative stress
dna methylation
data analysis
genome wide
neural network