Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model.
Guillaume PoliquinDuane FunkShane JonesKaylie TranCharlene RanadheeraMable HaganKevin TierneyAllen GrollaAmrinder DhaliwalAlexander BelloAnders LeungCory NakamuraDarwyn KobasaDarryl FalzaranoLauren GarnettHugues Fausther BovendoHeinz FeldmannMurray KesselmanGregory HansenJason GrenGeorge RisiMia BiondiTodd MortimerTrina RacineYvon DeschambaultSam AminianJocelyn EdmondsRay SouretteMark AllanLauren RondeauSharron HadderChristy PressChristine DeGraffStephanie KucasBradley W M CookB J HancockAnand KumarReeni SoniDarryl SchantzJarrid McKitrickBryce WarnerBryan D GriffinXiangguo QiuGary P KobingerDave SafronetzDerek SteinTodd CuttsJames KennyGeoff SouleRobert KozakSteven TheriaultLiam MenecRobert VendramelliSean HigginsGuodong LiuNiaz Md RahimSamantha KasloffAngela SloanShihua HeNikesh TailorMichael GrayJames E StrongPublished in: Intensive care medicine experimental (2019)
The model employed for this study is reflective of an intramuscular infection in humans (e.g., needle stick) and is highly lethal to NHPs. Using this model, we found that the animals developed progressive severe organ dysfunction and profound shock preceding death. While the overall impact of supportive care on the observed pathophysiology was limited, we did observe some time-dependent positive responses. Since this model is highly lethal, it does not reflect the full spectrum of human EVD. Our findings support the need for continued development of animal models that replicate the spectrum of human disease as well as ongoing development of anti-Ebola therapies to complement supportive care.