In vitro validation of helium ion irradiations as a function of linear energy transfer in radioresistant human malignant cells.
Aleksandra M Ristić FiraOtilija D KetaVladana D PetkovićMiloš ĐorđevićGiada PetringaSerena FattoriRoberto CatalanoGiuseppe Antonio Pablo CirroneGiacomo CuttoneDousatsu SakataNgoc Hoang TranKonstantinos P ChatzipapasSebastien IncertiAleksandra M Ristić FiraPublished in: International journal of radiation biology (2024)
Analyses of data acquired for the three cell lines irradiated by helium ions, having different LET, reveal high elimination capacity and creation of a large number of DNA DSB with respect to γ-rays, and are between those reported for protons and carbon ions.
Keyphrases
- energy transfer
- quantum dots
- induced apoptosis
- endothelial cells
- cell cycle arrest
- circulating tumor
- electronic health record
- aqueous solution
- genome wide
- big data
- endoplasmic reticulum stress
- pluripotent stem cells
- water soluble
- signaling pathway
- gene expression
- dna methylation
- cell death
- pi k akt
- deep learning
- cell proliferation
- nucleic acid