PIM3 Promotes the Proliferation and Migration of Acute Myeloid Leukemia Cells.
Hongmei LuoRuixue SunYuhuan ZhengJingcao HuangFangfang WangDan LongYu WuPublished in: OncoTargets and therapy (2020)
Our findings suggest that PIM3 regulates the proliferation, survival, and chemotaxis of AML cell lines. Moreover, pCXCR4 might mediate the regulation of PIM3-induced chemotaxis. Therefore, the inhibition of PIM3 expression may be a promising therapeutic target in AML.