Analysis of oxidative stress indicators in Polish patients with prostate cancer.
Joanna Maria Dróżdż-AfeltBeata Barbara Koim-PuchowskaPiotr KaminskiPublished in: Environmental science and pollution research international (2021)
The aim of the study was to analyze the activity of antioxidant enzymes (glutathione S-transferase, catalase, superoxide dismutase) and the concentration of malondialdehyde in order to determine the role of detoxification mechanisms in prostate cancer. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST) were measured using ready-made kits; lipid peroxidation intensity was determined by the thiobarbituric acid method. Superoxide dismutase was the only enzyme among antioxidant and detoxification enzymes for which a statistically significant difference in activity was found between the studied groups (1.4 U·ml-1 in patients vs. 1.6 U·ml-1 in control). No statistically significant differences were found for GST, CAT or the concentration of MDA between the group of men with prostate cancer and the control group. The lower SOD activity in men with prostate cancer may be due to a deficiency in their antioxidant defense system.
Keyphrases
- prostate cancer
- oxidative stress
- radical prostatectomy
- hydrogen peroxide
- end stage renal disease
- anti inflammatory
- ejection fraction
- chronic kidney disease
- newly diagnosed
- ischemia reperfusion injury
- prognostic factors
- nitric oxide
- cell death
- fatty acid
- diabetic rats
- peritoneal dialysis
- high intensity
- induced apoptosis
- amyotrophic lateral sclerosis
- endoplasmic reticulum stress
- solid state
- heat shock