Safety and efficacy of aged garlic extract in dogs: upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II antioxidant enzymes.
Osamu YamatoTadamitsu TsuneyoshiMitsuyasu UshijimaHiroshi JikiharaAkira YabukiPublished in: BMC veterinary research (2018)
The long-term oral administration of AGE at a dose of 90 mg/kg/day for 12 weeks did not show any adverse effects in dogs. Furthermore, the administration of AGE upregulated the gene expressions of canine Nrf2 and Nrf2-regulated phase II antioxidant enzymes. These results suggest that AGE might safely contribute to the health of dogs provided that the appropriate dosage is used.
Keyphrases
- phase ii
- oxidative stress
- clinical trial
- open label
- nuclear factor
- signaling pathway
- induced apoptosis
- double blind
- toll like receptor
- phase iii
- anti inflammatory
- placebo controlled
- healthcare
- public health
- mental health
- epithelial mesenchymal transition
- genome wide
- risk assessment
- copy number
- poor prognosis
- health information
- human health