Disulfide High-Mobility Group Box 1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation.

Rebecca A Sosa Allyson Q TerryFady M KaldasYi-Ping JinMaura RossettiTakahiro ItoFang LiRichard S AhnBita V NainiVictoria M GroysbergYing ZhengAntony AzizJessica Nevarez-MejiaAli ZarrinparRonald W BusuttilDavid W GjertsonJerzy W Kupiec-WeglinskiElaine F Reed

Published in: Hepatology (Baltimore, Md.) (2020)

These data identify disulfide-HMGB1 as a mechanistic biomarker of, and therapeutic target for, minimizing sterile inflammation during human liver IRI.

Keyphrases

endothelial cells
oxidative stress
transcription factor
electronic health record
pluripotent stem cells
big data
binding protein
machine learning