Predictors of poor function in RA based on two prospective UK inception cohorts. Do comorbidities matter?

Comorbidities at baseline have not been found to be associated with worse RA functional outcome in the long-term. On the other hand, sociodemographic factors, independently of disease measures, are associated with worse functional outcome in RA at five and 10 years, in models adjusting for comorbidity burden. Tailoring management interventions according to not only clinical disease parameters but also patient sociodemographic factors, may improve long-term outcomes including functional disability.