Statin inhibits large hepatitis delta antigen-Smad3 -twist-mediated epithelial-to-mesenchymal transition and hepatitis D virus secretion.

Yuh-Jin LiangCheng-Pu SunYu-Chen HsuYi-Wen ChenI-An WangChien-Wei SuMi-Hua TaoJaw-Ching Wu

Published in: Journal of biomedical science (2020)

We demonstrate that L-HDAg activates EMT via Twist and TGF-β activation. Treatment with statins suppressed Twist expression, and TGF-β secretion, leading to downregulation of EMT. Our findings clarify the mechanism of HDV-induced EMT, and provide a basis for possible novel therapeutic strategies against HDV infection.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
signaling pathway
cardiovascular disease
poor prognosis
high glucose
coronary artery disease
diabetic rats
oxidative stress
binding protein
disease virus