Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD.

Yufeng HuWenzhi HeYongping HuangHui XiangJuan GuoYan CheXu ChengFengjiao HuMan-Li HuTengfei MaJie YuHan TianSong TianYan-Xiao JiPeng ZhangZhi-Gang SheXiao-Jing ZhangZan HuangJuan YangHongliang Li

Published in: Hepatology (Baltimore, Md.) (2021)

These data indicate that SNX8 is a key suppressor of NAFLD that promotes FASN proteasomal degradation. Targeting the SNX8-FASN axis is a promising strategy for NAFLD prevention and treatment.

Keyphrases

fatty acid
electronic health record
genome wide
gene expression
machine learning
combination therapy
drug delivery
artificial intelligence
smoking cessation