The low-expression programming of 11β-HSD2 mediates osteoporosis susceptibility induced by prenatal caffeine exposure in male offspring rats.

Hao XiaoZhixin WuBin LiYangfan ShangguanJean-François StoltzJacques MagdalouLiaobin ChenHui Wang

Published in: British journal of pharmacology (2020)

PCE caused osteoporosis susceptibility in male adult offspring, which attributed to the low-functional programming of 11β-HSD2 induced by corticosterone via GR/HDAC11 signalling.

Keyphrases

postmenopausal women
high fat diet
bone mineral density
poor prognosis
pregnant women
adipose tissue
young adults
histone deacetylase