The nuclear retinoid-related orphan receptor RORα controls adipose tissue inflammation in patients with morbid obesity and diabetes.
Rebeca OrtegaLuisa HuesoEsther BenitoJoaquín OrtegaMiguel CiveraMaria-Jesus SanzJosé T RealLaura PiquerasPublished in: International journal of obesity (2005) (2021)
RORα blockade represents a potential therapy to prevent AT dysfunction and inflammation associated with insulin resistance in human obesity.
Keyphrases
- insulin resistance
- oxidative stress
- adipose tissue
- type diabetes
- metabolic syndrome
- weight loss
- high fat diet induced
- endothelial cells
- weight gain
- bariatric surgery
- high fat diet
- cardiovascular disease
- glycemic control
- skeletal muscle
- induced pluripotent stem cells
- body mass index
- pluripotent stem cells
- human health
- obese patients
- bone marrow
- mesenchymal stem cells
- replacement therapy
- smoking cessation