Meta-analysis: Prevalence of significant or advanced fibrosis in adults with alpha-1-antitrypsin deficiency.

Daniel Q HuangKai En ChanCaitlyn TanRebecca Wenling ZengBenjamin KohElden Yen Hng OngCharlotte Chung Hui OngChristen En Ya OngDarren J H TanWen Hui LimElina ChoEunice X X TanMargaret L P TengCheng-Han NgBenjamin NahMei Chin LimMark Dhinesh MuthiahVirginia C ClarkStephen Caldwell

Published in: Alimentary pharmacology & therapeutics (2023)

More than one in five adult individuals with AAT deficiency and Z homozygosity harbour significant fibrosis, and nearly 1 in 10 harbours advanced fibrosis. The risk of fibrosis increases incrementally with the frequency of Pi*Z mutations.

Keyphrases

systematic review
liver fibrosis
risk factors
randomized controlled trial
replacement therapy
young adults