Cancer Risk Following Bariatric Surgery-Systematic Review and Meta-analysis of National Population-Based Cohort Studies.
Tom WigginsStefan S AntonowiczSheraz Rehan MarkarPublished in: Obesity surgery (2020)
This study has analyzed results from registry-based population studies to assess the effect of bariatric surgery upon cancer incidence at a population level. Relevant studies were identified and meta-analysis was used to calculate pooled odds ratios (POR) for the incidence of cancer after bariatric surgery compared to controls. Eight population-based studies were included with 635,642 total patients. Bariatric surgery was associated with a significant reduction in overall cancer incidence (POR = 0.72; 95% CI 0.59 to 0.87; p = 0.0007) and incidence of obesity-related cancer (POR = 0.55; 95% CI 0.31 to 0.96; p = 0.04). Bariatric surgery was also protective for breast cancer development (POR = 0.50; 95% CI 0.25 to 0.99; p = 0.045). Bariatric surgery appears to be associated with a reduction in cancer incidence at a population-based level.
Keyphrases
- bariatric surgery
- papillary thyroid
- weight loss
- risk factors
- squamous cell
- obese patients
- ejection fraction
- end stage renal disease
- childhood cancer
- lymph node metastasis
- young adults
- physical activity
- randomized controlled trial
- insulin resistance
- body mass index
- chronic kidney disease
- skeletal muscle
- open label
- quality improvement