Radiogenomics Reveals Correlation between Quantitative Texture Radiomic Features of Biparametric MRI and Hypoxia-Related Gene Expression in Men with Localised Prostate Cancer.
Chidozie N OgbonnayaBasim S O AlsaediAbeer J AlhussainiRobert HislopNorman PrattGhulam NabiPublished in: Journal of clinical medicine (2023)
This study found that there is a correlation between the radiomic texture features extracted from bpMRI in localised prostate cancer and the hypoxia-related genes that are differentially expressed. The analysis of expression data based on cBioportal revealed that these hypoxia-related genes, which were the focus of the study, are linked to an unfavourable survival outcomes in prostate cancer patients.
Keyphrases
- prostate cancer
- gene expression
- radical prostatectomy
- contrast enhanced
- endothelial cells
- dna methylation
- poor prognosis
- magnetic resonance imaging
- high resolution
- computed tomography
- mass spectrometry
- single cell
- big data
- deep learning
- middle aged
- binding protein
- benign prostatic hyperplasia
- magnetic resonance
- data analysis