Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria.
Andrew D GrausteinElizabeth A MischMunyaradzi MusvosviMuki Shehu SheyJaveed A ShahChetan SeshadriAugustine AjuoguKathryn BowmanHumphrey MulengaAshley VeldsmanWillem A HanekomMark HatherillThomas J ScribaThomas R HawnPublished in: PloS one (2018)
Among infants, an HSP90B1 gene-region variant is associated with BCG-induced IL-2 production and may be associated with protection from TB disease. HSP90B1 knockdown in human monocyte-like cell lines did not influence TLR2 surface localization nor Mtb replication. Together, these data suggest that HSP90B1 regulates T-cell, but not monocyte, responses to mycobacteria in humans.
Keyphrases
- toll like receptor
- heat shock protein
- heat shock
- immune response
- endothelial cells
- heat stress
- dendritic cells
- inflammatory response
- nuclear factor
- mycobacterium tuberculosis
- high glucose
- genome wide
- peripheral blood
- oxidative stress
- dna methylation
- big data
- pulmonary tuberculosis
- pluripotent stem cells
- artificial intelligence