Comparative Effectiveness of Switching From First-Generation Basal Insulin to Glargine 300 U/ml or Degludec 100 U/ml in Type 1 Diabetes: The RESTORE-1 Study.

Luigi LaviolaFrancesca PorcellatiDaniela BruttomessoMonica LarosaMaria Chiara RossiAntonio Nicoluccinull null

Published in: Diabetes therapy : research, treatment and education of diabetes and related disorders (2020)

Switching from 1BI to 2BI in adults with T1D was associated with similar improvements in glycemic control and overall significant decrease in hypoglycemia, with no severe events with Gla-300. Effectiveness of both insulins was limited by under-titration.

Keyphrases

glycemic control
type diabetes
blood glucose
weight loss
insulin resistance
randomized controlled trial
systematic review
cardiovascular disease
early onset
adipose tissue
skeletal muscle