Single-cell profiling of sarcomas from archival tissue reveals programs associated with resistance to immune checkpoint blockade.

Karan Luthria Parin Shah Blake Caldwell Johannes C Melms Sinan Abuzaid Viktoria Jakubikova D Zack Brodtman Sminu Bose Amit Dipak Amin Patricia Ho Jana Biermann Somnath Tagore Matthew A Ingham Gary K Schwartz Benjamin Izar

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

This study provides a framework for studying rare tumors and identifies salient and treatment-associated cancer cell intrinsic and tumor-microenvironmental features in sarcomas.

Keyphrases

single cell
high grade
rna seq
public health
high throughput
dna methylation