Benjamin Izar

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 62

Top Venues

Nature cancer

Nature communications

Nature genetics

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Dhiraj Kumar, Sreeharsha Gurrapu, Yan Wang, Seong-Yeon Bae, Poonam R Pandey, Hong Chen, Jayanta Mondal, Hyun Ho Han, Chang-Jiun Wu, Spyros Karaiskos, Fei Yang, Aysegul Sahin, Ignacio I Wistuba, Jianjun Gao, Debasish Tripathy, Hua Gao, Benjamin Izar, Filippo G Giancotti
LncRNA Malat1 suppresses pyroptosis and T cell-mediated killing of incipient metastatic cells. Nature cancer (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer (2024)
Karan Luthria, Parin Shah, Blake Caldwell, Johannes C Melms, Sinan Abuzaid, Viktoria Jakubikova, D Zack Brodtman, Sminu Bose, Amit Dipak Amin, Patricia Ho, Jana Biermann, Somnath Tagore, Matthew A Ingham, Gary K Schwartz, Benjamin Izar
Single-cell profiling of sarcomas from archival tissue reveals programs associated with resistance to immune checkpoint blockade. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Zachary H Walsh, Parin Shah, Neeharika Kothapalli, Shivem B Shah, Gergő Nikolényi, D Zack Brodtman, Giuseppe Leuzzi, Meri Rogava, Michael Mu, Patricia Ho, Sinan Abuzaid, Neil Vasan, Mohammed AlQuraishi, Joshua D Milner, Alberto Ciccia, Johannes C Melms, Benjamin Izar
Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens. Nature biotechnology (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Melody DiBona, Yanyang Chen, Albert S Agustinus, Alice Mazzagatti, Mercedes A Duran, Matthew Deyell, Daniel Bronder, James H Hickling, Christy Hong, Lorenzo Scipioni, Giulia Tedeschi, Sara Martin, Jun Li, Aušrinė Ruzgaitė, Nadeem Riaz, Parin Shah, Edridge K D'Souza, D Zack Brodtman, Simone Sidoli, Bill Diplas, Manisha Jalan, Nancy Y Lee, Alban Ordureau, Benjamin Izar, Ashley M Laughney, Simon N Powell, Enrico Gratton, Stefano Santaguida, John Maciejowski, Peter Ly, Thomas M Jeitner, Samuel F Bakhoum
Micronuclear collapse from oxidative damage. Science (New York, N.Y.) 385 (6712) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Dhiraj Kumar, Sreeharsha Gurrapu, Yan Wang, Seong-Yeon Bae, Poonam R Pandey, Hong Chen, Jayanta Mondal, Hyun Ho Han, Chang-Jiun Wu, Spyros Karaiskos, Fei Yang, Aysegul Sahin, Ignacio I Wistuba, Jianjun Gao, Debasish Tripathy, Hua Gao, Benjamin Izar, Filippo G Giancotti
LncRNA Malat1 suppresses pyroptosis and T cell-mediated killing of incipient metastatic cells. Nature cancer 5 (2) (2024)
Miguel A Ibarra-Arellano, Lindsay A Caprio, Aroj Hada, Niklas Stotzem, Luke L Cai, Shivem B Shah, Johannes C Melms, Florian Wünneman, Benjamin Izar, Denis Schapiro
micronuclAI: Automated quantification of micronuclei for assessment of chromosomal instability. bioRxiv : the preprint server for biology (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer (2024)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 15 (1) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 15 (1) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Zachary H Walsh, Parin Shah, Neeharika Kothapalli, Shivem B Shah, Gergő Nikolényi, D Zack Brodtman, Giuseppe Leuzzi, Meri Rogava, Michael Mu, Patricia Ho, Sinan Abuzaid, Neil Vasan, Mohammed AlQuraishi, Joshua D Milner, Alberto Ciccia, Johannes C Melms, Benjamin Izar
Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens. Nature biotechnology (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Dhiraj Kumar, Sreeharsha Gurrapu, Yan Wang, Seong-Yeon Bae, Poonam R Pandey, Hong Chen, Jayanta Mondal, Hyun Ho Han, Chang-Jiun Wu, Spyros Karaiskos, Fei Yang, Aysegul Sahin, Ignacio I Wistuba, Jianjun Gao, Debasish Tripathy, Hua Gao, Benjamin Izar, Filippo G Giancotti
LncRNA Malat1 suppresses pyroptosis and T cell-mediated killing of incipient metastatic cells. Nature cancer 5 (2) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 15 (1) (2024)
Casey R Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Aleksandar Obradovic, Meri Rogava, Johannes C Melms, Patrick McCann, Catherine Spina, Charles G Drake, Matthew C Dallos, Benjamin Izar
KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response. bioRxiv : the preprint server for biology (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
Yiping Wang, Joy Linyue Fan, Johannes C Melms, Amit Dipak Amin, Yohanna Georgis, Irving Barrera, Patricia Ho, Somnath Tagore, Gabriel Abril-Rodríguez, Siyu He, Yinuo Jin, Jana Biermann, Matan Hofree, Lindsay Caprio, Simon Berhe, Shaheer A Khan, Brian S Henick, Antoni Ribas, Evan Z Macosko, Fei Chen, Alison M Taylor, Gary K Schwartz, Richard D Carvajal, Elham Azizi, Benjamin Izar
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens. Nature genetics (2023)
Gino Kim In, Jennifer R Ribeiro, Jun Yin, Joanne Xiu, Matias A Bustos, Fumito Ito, Frances E Chow, Gabriel Zada, Lindsay Hwang, April K S Salama, Soo J Park, Justin C Moser, Sourat Darabi, Evidio Domingo-Musibay, Maria L Ascierto, Kim Margolin, Jose Lutzky, Geoffrey T Gibney, Michael B Atkins, Benjamin Izar, Dave S B Hoon, Ari M VanderWalde
Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases. NPJ precision oncology 7 (1) (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
Everardo Hegewisch-Solloa, Janine E Melsen, Hiranmayi Ravichandran, André F Rendeiro, Aharon G Freud, Bethany Mundy-Bosse, Johannes C Melms, Shira E Eisman, Benjamin Izar, Eli Grunstein, Thomas J Connors, Olivier Elemento, Amir Horowitz, Emily M Mace
Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry and high-resolution microscopy. bioRxiv : the preprint server for biology (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
Zachary H Walsh, Parin Shah, Neeharika Kothapalli, Gergo Nikolenyi, Shivem B Shah, Giuseppe Leuzzi, Michael Mu, Patricia Ho, Sinan Abuzaid, Zack D Brodtman, Neil Vasan, Mohammed AlQuraishi, Joshua D Milner, Alberto Ciccia, Johannes C Melms, Benjamin Izar
Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells. bioRxiv : the preprint server for biology (2023)
David Hou, Brandyn Castro, Mark Dapash, Andrew Zolp, Joshua Katz, Víctor Arrieta, Jana Biermann, Johannes C Melms, Jan Kueckelhaus, Jasim Benotmane, Mark Youngblood, Aida Rashidi, Leah Billingham, Crismita Dmello, Gustavo Vazquez-Cervantes, Aurora Lopez-Rosas, Yu Han, Ronit Patel, Tzu-Yi Chia, Lu Sun, Robert M Prins, Benjamin Izar, Deiter Henrik Heiland, Peng Zhang, Adam M Sonabend, Jason M Miska, Maciej Lesniak, Junfei Zhao, Catalina Lee-Chang
B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression. Research square (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
Casey R Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Somnath Tagore, Aleksandar Obradovic, Collin Jugler, Meri Rogava, Johannes C Melms, Patrick McCann, Catherine Spina, Charles G Drake, Matthew C Dallos, Benjamin Izar
KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response. Journal for immunotherapy of cancer 11 (9) (2023)
Zachary H Walsh, Parin Shah, Neeharika Kothapalli, Gergo Nikolenyi, Shivem B Shah, Giuseppe Leuzzi, Michael Mu, Patricia Ho, Sinan Abuzaid, Zack D Brodtman, Neil Vasan, Mohammed AlQuraishi, Joshua D Milner, Alberto Ciccia, Johannes C Melms, Benjamin Izar
Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells. bioRxiv : the preprint server for biology (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
Yiping Wang, Joy Linyue Fan, Johannes C Melms, Amit Dipak Amin, Yohanna Georgis, Irving Barrera, Patricia Ho, Somnath Tagore, Gabriel Abril-Rodríguez, Siyu He, Yinuo Jin, Jana Biermann, Matan Hofree, Lindsay Caprio, Simon Berhe, Shaheer A Khan, Brian S Henick, Antoni Ribas, Evan Z Macosko, Fei Chen, Alison M Taylor, Gary K Schwartz, Richard D Carvajal, Elham Azizi, Benjamin Izar
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens. Nature genetics 55 (1) (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
Johannes C Melms, Patricia Ho, Meri Rogava, Benjamin Izar
From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6. Genes and immunity (2023)
Yiping Wang, Joy Linyue Fan, Johannes C Melms, Amit Dipak Amin, Yohanna Georgis, Irving Barrera, Patricia Ho, Somnath Tagore, Gabriel Abril-Rodríguez, Siyu He, Yinuo Jin, Jana Biermann, Matan Hofree, Lindsay Caprio, Simon Berhe, Shaheer A Khan, Brian S Henick, Antoni Ribas, Evan Z Macosko, Fei Chen, Alison M Taylor, Gary K Schwartz, Richard D Carvajal, Elham Azizi, Benjamin Izar
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens. Nature genetics 55 (1) (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
Jun Li, Melissa J Hubisz, Ethan M Earlie, Mercedes A Duran, Christy Hong, Austin A Varela, Emanuele Lettera, Matthew Deyell, Bernardo Tavora, Jonathan J Havel, Su M Phyu, Amit Dipak Amin, Karolina Budre, Erina Kamiya, Julie-Ann Cavallo, Christopher Garris, Simon N Powell, Jorge Sergio Reis-Filho, Hannah Wen, Sarah Bettigole, Atif J Khan, Benjamin Izar, Eileen E Parkes, Ashley M Laughney, Samuel F Bakhoum
Non-cell-autonomous cancer progression from chromosomal instability. Nature (2023)
Yiping Wang, Joy Linyue Fan, Johannes C Melms, Amit Dipak Amin, Yohanna Georgis, Irving Barrera, Patricia Ho, Somnath Tagore, Gabriel Abril-Rodríguez, Siyu He, Yinuo Jin, Jana Biermann, Matan Hofree, Lindsay Caprio, Simon Berhe, Shaheer A Khan, Brian S Henick, Antoni Ribas, Evan Z Macosko, Fei Chen, Alison M Taylor, Gary K Schwartz, Richard D Carvajal, Elham Azizi, Benjamin Izar
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens. Nature genetics 55 (1) (2023)
Ronald A DePinho, Joan Massagué, Gulam Manji, Anil K Rustgi, Benjamin Izar
Filippo Giancotti (1958-2023). Nature cancer (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
David Hou, Brandyn Castro, Mark Dapash, Andrew Zolp, Joshua Katz, Víctor Arrieta, Jana Biermann, Johannes C Melms, Jan Kueckelhaus, Jasim Benotmane, Mark Youngblood, Aida Rashidi, Leah Billingham, Crismita Dmello, Gustavo Vazquez-Cervantes, Aurora Lopez-Rosas, Yu Han, Ronit Patel, Tzu-Yi Chia, Lu Sun, Robert M Prins, Benjamin Izar, Deiter Henrik Heiland, Peng Zhang, Adam M Sonabend, Jason M Miska, Maciej Lesniak, Junfei Zhao, Catalina Lee-Chang
B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression. Research square (2023)
David Hou, Brandyn Castro, Mark Dapash, Andrew Zolp, Joshua Katz, Víctor Arrieta, Jana Biermann, Johannes C Melms, Jan Kueckelhaus, Jasim Benotmane, Mark Youngblood, Aida Rashidi, Leah Billingham, Crismita Dmello, Gustavo Vazquez-Cervantes, Aurora Lopez-Rosas, Yu Han, Ronit Patel, Tzu-Yi Chia, Lu Sun, Robert M Prins, Benjamin Izar, Deiter Henrik Heiland, Peng Zhang, Adam M Sonabend, Jason M Miska, Maciej Lesniak, Junfei Zhao, Catalina Lee-Chang
B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression. Research square (2023)
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christos, Ashish Saxena, Olivier Elemento, Bhavneet Bhinder, Casey Ager, Amit Dipak Amin, Nicholas J Sanfilippo, Vivek Mittal, Alain C Borczuk, Sylvia C Formenti, Benjamin Izar, Timothy E McGraw
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications 14 (1) (2023)
Yiping Wang, Joy Linyue Fan, Johannes C Melms, Amit Dipak Amin, Yohanna Georgis, Irving Barrera, Patricia Ho, Somnath Tagore, Gabriel Abril-Rodríguez, Siyu He, Yinuo Jin, Jana Biermann, Matan Hofree, Lindsay Caprio, Simon Berhe, Shaheer A Khan, Brian S Henick, Antoni Ribas, Evan Z Macosko, Fei Chen, Alison M Taylor, Gary K Schwartz, Richard D Carvajal, Elham Azizi, Benjamin Izar
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens. Nature genetics 55 (1) (2023)
Yiping Wang, Joy Linyue Fan, Johannes C Melms, Amit Dipak Amin, Yohanna Georgis, Irving Barrera, Patricia Ho, Somnath Tagore, Gabriel Abril-Rodríguez, Siyu He, Yinuo Jin, Jana Biermann, Matan Hofree, Lindsay Caprio, Simon Berhe, Shaheer A Khan, Brian S Henick, Antoni Ribas, Evan Z Macosko, Fei Chen, Alison M Taylor, Gary K Schwartz, Richard D Carvajal, Elham Azizi, Benjamin Izar
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens. Nature genetics 55 (1) (2023)
Anna C Pavlick, Charlotte E Ariyan, Elizabeth I Buchbinder, Diwakar Davar, Geoffrey Thomas Gibney, Omid Hamid, Tina J Hieken, Benjamin Izar, Douglas B Johnson, Rajan P Kulkarni, Jason John Luke, Tara C Mitchell, Meghan J Mooradian, Krista M Rubin, April Ks Salama, Keisuke Shirai, Janis M Taube, Hussein A Tawbi, J Keith Tolley, Caressa Valdueza, Sarah A Weiss, Michael K Wong, Ryan J Sullivan
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0. Journal for immunotherapy of cancer 11 (10) (2023)
Huachao Huang, Yinshan Fang, Ming Jiang, Yihan Zhang, Jana Biermann, Johannes C Melms, Jennifer A Danielsson, Ying Yang, Li Qiang, Jia Liu, Yiwu Zhou, Manli Wang, Zhihong Hu, Timothy C Wang, Anjali Saqi, Jie Sun, Ichiro Matsumoto, Wellington V Cardoso, Charles W Emala, Jian Zhu, Benjamin Izar, Hongmei Mou, Dominique Bailey
Contribution of Trp63 CreERT2 -labeled cells to alveolar regeneration is independent of tuft cells. eLife 11 (2022)
Aveline Filliol, Yoshinobu Saito, Bindu Nair, Dianne H Dapito, Le-Xing Yu, Aashreya Ravichandra, Sonakshi Bhattacharjee, Silvia Affo, Naoto Fujiwara, Hua Su, Qiuyan Sun, Thomas M Savage, John R Wilson-Kanamori, Jorge M Caviglia, LiKang Chin, Dongning Chen, Xiaobo Wang, Stefano Caruso, Jin Ku Kang, Amit Dipak Amin, Sebastian J Wallace, Ross Dobie, Deqi Yin, Oscar M Rodriguez-Fiallos, Chuan Yin, Adam Mehal, Benjamin Izar, Richard A Friedman, Rebecca G Wells, Utpal B Pajvani, Yujin Hoshida, Helen E Remotti, Nicholas Arpaia, Jessica Zucman-Rossi, Michael Karin, Neil Cowan Henderson, Ira Tabas, Robert F Schwabe
Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature 610 (7931) (2022)
Christopher Alvarez-Breckenridge, Samuel C Markson, Jackson H Stocking, Naema Nayyar, Matt Lastrapes, Matthew R Strickland, Albert E Kim, Magali A de Sauvage, Ashish Dahal, Juliana M Larson, Joana Liliana Mora, Andrew W Navia, Robert H Klein, Benjamin M Kuter, Corey M Gill, Mia S Bertalan, Brian Shaw, Alexander Kaplan, Megha Subramanian, Aarushi Jain, Swaminathan Kumar, Husain H Danish, Michael D White, Osmaan Shahid, Kristen E Pauken, Brian C Miller, Dennie T Frederick, Christine Hebert, McKenzie L Shaw, Maria Martinez-Lage, Matthew P Frosch, Nancy Wang, Elizabeth R Gerstner, Brian Vala Nahed, William T Curry, Bob S Carter, Daniel P Cahill, Genevieve Marie Boland, Benjamin Izar, Michael A Davies, Arlene H Sharpe, Mario L Suvà, Ryan J Sullivan, Priscilla Kaliopi Brastianos, Scott L Carter
Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition. Cancer immunology research 10 (8) (2022)
Johannes C Melms, Jana Biermann, Huachao Huang, Yiping Wang, Bindu Nair, Somnath Tagore, Igor Katsyv, André F Rendeiro, Amit Dipak Amin, Denis Schapiro, Chris J Frangieh, Adrienne M Luoma, Aveline Filliol, Yinshan Fang, Hiranmayi Ravichandran, Mariano G Clausi, George A Alba, Meri Rogava, Sean W Chen, Patricia Ho, Daniel T Montoro, Adam E Kornberg, Arnold S Han, Mathieu F Bakhoum, Niroshana Anandasabapathy, Mayte Suárez-Fariñas, Samuel F Bakhoum, Yaron Bram, Alain Borczuk, Xinzheng V Guo, Jay H Lefkowitch, Charles Marboe, Stephen M Lagana, Armando Del Portillo, Emily J Tsai, Emmanuel Zorn, Glen S Markowitz, Robert F Schwabe, Robert E Schwartz, Olivier Elemento, Anjali Saqi, Hanina Hibshoosh, Dominique Bailey, Benjamin Izar
A molecular single-cell lung atlas of lethal COVID-19. Nature 595 (7865) (2021)
Toni Marie Delorey, Carly G K Ziegler, Graham Heimberg, Rachelly Normand, Yiming Yang, Åsa Segerstolpe, Domenic Abbondanza, Stephen J Fleming, Ayshwarya Subramanian, Daniel T Montoro, Karthik A Jagadeesh, Kushal K Dey, Pritha Sen, Michal Slyper, Yered H Pita-Juárez, Devan Phillips, Jana Biermann, Zohar Bloom-Ackermann, Nikolaos Barkas, Andrea Ganna, James Gomez, Johannes C Melms, Igor Katsyv, Erica Normandin, Pourya Naderi, Yury V Popov, Siddharth S Raju, Sebastian Niezen, Linus T-Y Tsai, Katherine J Siddle, Malika Sud, Victoria M Tran, Shamsudheen K Vellarikkal, Yiping Wang, Liat Amir-Zilberstein, Deepak S Atri, Joseph Beechem, Olga R Brook, Jonathan Chen, Prajan Divakar, Phylicia Dorceus, Jesse M Engreitz, Adam Essene, Donna M Fitzgerald, Robin Fropf, Steven Gazal, Joshua Gould, John Grzyb, Tyler Harvey, Jonathan Hecht, Tyler Hether, Judit Jané-Valbuena, Michael Leney-Greene, Hui Ma, Cristin McCabe, Daniel E McLoughlin, Eric M Miller, Christoph Muus, Mari Niemi, Robert Padera, Liuliu Pan, Deepti Pant, Carmel Pe'er, Jenna Pfiffner-Borges, Christopher J Pinto, Jacob Plaisted, Jason Reeves, Marty Ross, Melissa Rudy, Erroll H Rueckert, Michelle Siciliano, Alexander Sturm, Ellen Todres, Avinash Waghray, Sarah Warren, Shuting Zhang, Daniel R Zollinger, Lisa Cosimi, Rajat M Gupta, Nir Hacohen, Hanina Hibshoosh, Winston Hide, Alkes L Price, Jayaraj Rajagopal, Purushothama Rao Tata, Stefan Riedel, Gyongyi Szabo, Timothy L Tickle, Patrick T Ellinor, Deborah Hung, Pardis C Sabeti, Richard Novak, Robert Rogers, Donald E Ingber, Z Gordon Jiang, Dejan Juric, Mehrtash Babadi, Samouil L Farhi, Benjamin Izar, James R Stone, Ioannis S Vlachos, Isaac H Solomon, Orr Ashenberg, Caroline B M Porter, Bo Li, Alex K Shalek, Alexandra-Chloé Villani, Orit Rozenblatt-Rosen, Aviv Regev
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature 595 (7865) (2021)
Chris J Frangieh, Johannes C Melms, Pratiksha I Thakore, Kathryn R Geiger-Schuller, Patricia Ho, Adrienne M Luoma, Brian Cleary, Livnat Jerby, Shruti Malu, Michael S Cuoco, Maryann Zhao, Casey R Ager, Meri Rogava, Lila Hovey, Asaf Rotem, Chantale Bernatchez, Kai W Wucherpfennig, Bruce E Johnson, Orit Rozenblatt-Rosen, Dirk Schadendorf, Aviv Regev, Benjamin Izar
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion. Nature genetics 53 (3) (2021)
Livnat Jerby, Cyril Neftel, Marni E Shore, Hannah R Weisman, Nathan D Mathewson, Matthew J McBride, Brian Haas, Benjamin Izar, Angela Volorio, Gaylor Boulay, Luisa Cironi, Alyssa R Richman, Liliane C Broye, Joseph M Gurski, Christina C Luo, Ravindra Mylvaganam, Lan Nguyen, Shaolin Mei, Johannes C Melms, Christophe Georgescu, Ofir Cohen, Jorge E Buendia-Buendia, Asa Segerstolpe, Malika Sud, Michael S Cuoco, Danny Labes, Simon Gritsch, Daniel R Zollinger, Nicole Ortogero, Joseph M Beechem, G Petur Nielsen, Ivan Chebib, Tu Nguyen-Ngoc, Michael Montemurro, Gregory M Cote, Edwin Choy, Igor Letovanec, Stephane Cherix, Nikhil Wagle, Peter Karl Sorger, Alex B Haynes, John T Mullen, Ivan Stamenkovic, Miguel N Rivera, Cigall Kadoch, Kai W Wucherpfennig, Orit Rozenblatt-Rosen, Mario L Suvà, Nicolò Riggi, Aviv Regev
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma. Nature medicine 27 (2) (2021)
David Liu, Jia-Ren Lin, Emily J Robitschek, Gyulnara G Kasumova, Alex Heyde, Alvin Shi, Adam Kraya, Gao Zhang, Tabea Moll, Dennie T Frederick, Yu-An Chen, Shu Wang, Denis Schapiro, Li-Lun Ho, Kevin Bi, Avinash Sahu, Shaolin Mei, Benchun Miao, Tatyana Sharova, Christopher Alvarez-Breckenridge, Jackson H Stocking, Tommy Kim, Riley Fadden, Donald Lawrence, Mai P Hoang, Daniel P Cahill, Mohsen Malehmir, Martin A Nowak, Priscilla Kaliopi Brastianos, Christine G Lian, Eytan Ruppin, Benjamin Izar, Meenhard Herylyn, Eliezer Van Allen, Katherine L Nathanson, Keith T Flaherty, Ryan J Sullivan, Manolis Kellis, Peter Karl Sorger, Genevieve Marie Boland
Evolution of delayed resistance to immunotherapy in a melanoma responder. Nature medicine 27 (6) (2021)
Meng Xiao He, Michael S Cuoco, Jett Crowdis, Alice Bosma-Moody, Zhenwei Zhang, Kevin Bi, Abhay Kanodia, Mei-Ju Su, Sheng Yu Ku, Maria Mica Garcia, Amalia R Sweet, Christopher Rodman, Laura DelloStritto, Rebecca Silver, John Steinharter, Parin Shah, Benjamin Izar, Nathan C Walk, Kelly P Burke, Ziad Bakouny, Alok K Tewari, David Liu, Sabrina Y Camp, Natalie I Vokes, Keyan Salari, Jihye Park, Sébastien Vigneau, Lawrence Fong, Joshua W Russo, Xin Yuan, Steven P Balk, Himisha Beltran, Orit Rozenblatt-Rosen, Aviv Regev, Asaf Rotem, Mary-Ellen Taplin, Eliezer Van Allen
Transcriptional mediators of treatment resistance in lethal prostate cancer. Nature medicine 27 (3) (2021)
Johannes C Melms, Rohit Thummalapalli, Kristin Shaw, Huihui Ye, Leo Tsai, Rupal S Bhatt, Benjamin Izar
Alpha-fetoprotein (AFP) as tumor marker in a patient with urothelial cancer with exceptional response to anti-PD-1 therapy and an escape lesion mimic. Journal for immunotherapy of cancer 6 (1) (2018)
Jia-Ren Lin, Benjamin Izar, Shu Wang, Clarence Yapp, Shaolin Mei, Parin M Shah, Sandro Santagata, Peter Karl Sorger
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. eLife 7 (2018)
Benjamin Izar, William Sharfman, F Stephen Hodi, Donald Lawrence, Keith T Flaherty, Ravi Amaravadi, Kevin B Kim, Igor Puzanov, Jeffrey Sosman, Reinhard Dummer, Simone M Goldinger, Lyhping Lam, Shefali Kakar, Zhongwen Tang, Oliver Krieter, David F McDermott, Michael B Atkins
A first-in-human phase I, multicenter, open-label, dose-escalation study of the oral RAF/VEGFR-2 inhibitor (RAF265) in locally advanced or metastatic melanoma independent from BRAF mutation status. Cancer medicine 6 (8) (2017)

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Benjamin Izar