YWHAE as an HE4 interacting protein can influence the malignant behaviour of ovarian cancer by regulating the PI3K/AKT and MAPK pathways.

Xiao LiCaixia WangShuang WangYuexin HuShan JinOuxuan LiuRui GouXin NieJuanjuan LiuBei Lin

Published in: Cancer cell international (2021)

Altogether, this study demonstrates that YWHAE is substantially upregulated in ovarian cancer tissues, representing a risk factor for the prognosis of ovarian cancer that is positively correlated with HE4 expression. Furthermore, YWHAE and its downstream pathways may represent new therapeutic targets for ovarian cancer.

Keyphrases

poor prognosis
signaling pathway
oxidative stress
binding protein
cell proliferation
pi k akt
long non coding rna