Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases.
Guillermo BarturenSepideh BabaeiFrancesc Català-MollManuel Martínez-BuenoZuzanna MakowskaJordi Martorell-MarugánPedro Carmona-SáezDaniel Toro-DomínguezElena Carnero-MontoroMaría TeruelMartin KerickMarialbert Acosta-HerreraLucas Le LannChristophe JaminJavier Rodríguez-UbrevaAntonio García-GómezJorge KageyamaAnne ButtgereitSikander HayatJoerg MuellerRalf LescheMaria Hernandez-FuentesMaria JuarezTania RowleyIan WhiteConcepción MarañónTania Gomes AnjosNieves VarelaRocío Aguilar-QuesadaFrancisco Javier GarranchoAntonio López-BerrioManuel Rodriguez MarescaHéctor Navarro-LinaresIsabel AlmeidaNancy AzevedoMariana BrandãoAna CamparRaquel FariaFátima FarinhaAntónio MarinhoEsmeralda NevesAna TavaresCarlos VasconcelosElena TrombettaGaia MontanelliBarbara VigoneDamiana Alvarez-ErricoTianlu LiDivya ThiagaranRicardo Blanco AlonsoAlfonso Corrales MartínezFernanda GenreRaquel López MejíasMiguel Angel González-GaySara RemuzgoBegoña Ubilla GarciaRicard CerveraGerard EspinosaIgnasi Rodríguez-PintóEllen De LangheJonathan CremerRik LoriesDoreen BelzNicolas HunzelmannNiklas BaerleckenKatja KnieschTorsten WitteMichaela LehnerGeorg StummvollMichael ZaunerMaria Angeles Aguirre-ZamoranoNuria BarbarrojaMaria Carmen Castro-VillegasEduardo Collantes-EstevezEnrique de RamonIsabel Díaz QuinteroAlejandro Escudero-ContrerasMaría Concepción Fernández RoldánYolanda Jiménez GómezInmaculada Jiménez MoleónRosario Lopez-PedreraRafaela Ortega-CastroNorberto OrtegoEnrique RayaCarolina ArtusiMaria GerosaPier Luigi MeroniTommaso SchioppoAurélie De GroofJulie DucreuxBernard R LauwerysAnne-Lise MaudouxDivi CornecValérie Devauchelle-PensecSandrine Jousse-JoulinPierre-Emmanuel JouveBénédicte RouvièreAlain SarauxQuentin SimonMontserrat AlvarezCarlo ChizzoliniAleksandra DufourDonatienne WynarAttila BalogMárta BocskaiMagdolna DeákSonja DulicGabriella KádárLászló KovácsQingyu ChengVelia GerlFalk HiepeLaleh KhodadadiSilvia ThielEmanuele de RinaldisSambasiva RaoRobert J BenschopChris ChamberlainErnst R DowYiannis IoannouLaurence LaigleJacqueline MarovacJerome WojcikYves RenaudineauMaria Orietta BorghiJohan FrostegårdJavier MartínLorenzo BerettaEsteban BallestarFiona McDonaldJacques-Olivier PersMarta Eugenia Alarcón-RiquelmePublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Patients with systemic autoimmune diseases can be jointly stratified into 3 stable disease clusters with specific molecular patterns differentiating different molecular disease mechanisms. These results have important implications for future clinical trials and the study of nonresponse to therapy, marking a paradigm shift in our view of systemic autoimmune diseases.