Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma.

Hengyu ZhouYing CaiDina LiuMenghui LiYu ShaWenlu ZhangKai WangJianping GongNi TangAilong HuangJianguo Qiu

Published in: Cell proliferation (2018)

Pharmacological or transcriptional inhibition of HDAC1/2 increases p19INK4d and p21Waf1/Cip1 expression, decreases CDK expression and arrests HCC growth. These results indicated a potential pharmacological mechanism of selective HDAC1/2 inhibitors in HCC therapy.

Keyphrases

cell cycle
poor prognosis
cell proliferation
histone deacetylase
gene expression
transcription factor
long non coding rna
oxidative stress
cell death
binding protein
endoplasmic reticulum stress
heat shock
risk assessment
mesenchymal stem cells
cell cycle arrest
smoking cessation