Association between use of systemic and inhaled glucocorticoids and changes in brain volume and white matter microstructure: a cross-sectional study using data from the UK Biobank.

Merel van der MeulenJorge Miguel AmayaOlaf M DekkersOnno C Meijer

Published in: BMJ open (2022)

Both systemic and inhaled glucocorticoid use are associated with decreased white matter integrity and limited changes in GMV. This association may contribute to the neuropsychiatric side effects of glucocorticoid medication, especially with chronic use.

Keyphrases

white matter
multiple sclerosis
cystic fibrosis
electronic health record
healthcare
physical activity
drug induced
big data
cross sectional
adverse drug
machine learning