LOX and Its Methylation Impact Prognosis of Diseases and Correlate with TAM Infiltration in ESCA.

Chuanqiang Wu Bin Jiang Zixiang Wu Lingjun Dong Keyi Sun Ming Wu

Published in: Journal of oncology (2022)

The overexpression of LOX in ESCA is regulated by DNA hypomethylation; LOX overexpression or LOX hypomethylation can predict a worse prognosis in patients with ESCA. Besides, LOX may be involved in TIME regulation, promoting the infiltration levels and function of TAM. Hence, high LOX expression affected by DNA hypomethylation has an essential role in patients with ESCA, which may become an effective prognostic marker and therapeutic target.

Keyphrases

low density lipoprotein
cell proliferation
circulating tumor
single molecule
cell free
poor prognosis
transcription factor
dna methylation
gene expression
binding protein
nucleic acid
circulating tumor cells