The Improved Brain-Targeted Drug Delivery of Edaravone Temperature-Sensitive Gels by Ultrasound for γ-ray Radiation-Induced Brain Injury.
Qian LiYizhi ZhangJinglu HuBochuan YuanPengcheng ZhangYaxin WangXu JinLina DuYiguang JinPublished in: Pharmaceutics (2022)
Radiation-induced brain injury (RBI) is a common neurological disease caused by ionizing radiation (IR). Edaravone (EDA) is a free radical scavenger, has the potential to treat RBI. EDA loaded temperature-sensitive gels (TSGs) were prepared for subcutaneous injection to improve inconvenient administration of intravenous infusion. RBI mice model was established by irradiation of 60 Co γ-ray on head. EDA TSGs could improve spontaneous behavior, learning and memory and anxiety of RBI mice by behavior tests, including the open field test, the novel object recognition test, the elevated plus maze test and the fear conditioning test. The therapeutic effects were enhanced with the assistance of ultrasound. Alleviative pathological changes, decreased the expression of Molondialdehyde (MDA) and Interleukin-6 (IL-6) in the hippocampus of brain, indicated reduced oxidative stress and inflammatory response with the treatment of EDA TSGs and ultrasound. Moreover, ultrasound was superior to the use of EDA TSGs. Safe and effective EDA TSGs were prepared for RBI, and the feasibility of brain-targeted drug delivery enhanced by ultrasound was preliminarily demonstrated in this study.
Keyphrases
- brain injury
- radiation induced
- cerebral ischemia
- drug delivery
- subarachnoid hemorrhage
- magnetic resonance imaging
- cancer therapy
- radiation therapy
- ultrasound guided
- inflammatory response
- resting state
- oxidative stress
- contrast enhanced ultrasound
- white matter
- functional connectivity
- poor prognosis
- computed tomography
- type diabetes
- dna damage
- adipose tissue
- binding protein
- endoplasmic reticulum stress
- lps induced
- induced apoptosis
- ischemia reperfusion injury
- wild type