Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel.

Yang YuD M DalyI J AdamP KitsantaC J HillJ WildA ShorthouseD GrundyW Jiang

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2016)

Afferent sensitivity in human bowel was reduced with advancing age. Augmentation of mast cells and EC cell numbers and the mast cell-nerve association suggest a compensatory mechanism for sensory neurodegeneration.

Keyphrases

endothelial cells
induced pluripotent stem cells
induced apoptosis
pluripotent stem cells
stem cells
cell therapy
oxidative stress
mesenchymal stem cells
peripheral nerve