Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas.

Sean J JudgeMorgan A DarrowSteve W ThorpeAlicia A GingrichEdmond F O'DonnellAlyssa R BelliniIan R SturgillLogan V VickCordelia DunaiKevin M StoffelYue LyuShuai ChenMay ChoRobert B RebhunArta M MonjazebWilliam J MurphyRobert J Canter

Published in: Journal for immunotherapy of cancer (2021)

Intratumoral NK and T cells are prognostic in STS, but their activation is marked by significant upregulation of TIGIT. Our data suggest that combined IL-15 and TIGIT blockade may be a promising clinical strategy in STS.

Keyphrases

soft tissue
nk cells
poor prognosis
electronic health record
high grade
deep learning
data analysis