General, Practical and Selective Oxidation Protocol for CF₃S into CF₃S(O) Group.
Liubov V SokolenkoRaisa K OrlovaAndrey A FilatovYurii L YagupolskiiEmmanuel MagnierBruce PégotPatrick DiterPublished in: Molecules (Basel, Switzerland) (2019)
A simple and efficient protocol for the oxidation of trifluoromethyl, mono- and difluoromethyl sulfides to the corresponding sulfoxides without over-oxidation to sulfones, using TFPAA prepared in situ from trifluoroacetic acid and 15% H₂O₂ aqueous solution was developed. The methodology is suitable for a wide range of aromatic and aliphatic substrates in milligram and multigram scales.