Age-associated proteomic alterations in human aortic media.
Yuri MiuraHiroki TsumotoMachiko IwamotoYuya YamaguchiPojui KoYurie SoejimaShoko YoshidaTosifusa TodaTomio AraiAkihiko HamamatsuTamao EndoMotoji SawabePublished in: Geriatrics & gerontology international (2019)
Proteomic approaches showed that the elevated expression of lactadherin might contribute to amyloid deposition, enhancement of oxidative stress, induction of antioxidant proteins and matrix remodeling in older-aged aortic media. Geriatr Gerontol Int 2019; 19: 1054-1062.
Keyphrases
- oxidative stress
- aortic valve
- endothelial cells
- pulmonary artery
- poor prognosis
- left ventricular
- label free
- aortic dissection
- dna damage
- induced pluripotent stem cells
- diabetic rats
- physical activity
- ischemia reperfusion injury
- induced apoptosis
- binding protein
- anti inflammatory
- coronary artery
- middle aged
- long non coding rna
- atrial fibrillation
- heat shock