HDL cholesterol protects from liver injury in mice with intestinal specific LXRα activation.
Irene PierantonelliGessica LiociFabio GurradoDebora M GiordanoChiara RychlickiClaudia BoccaLuciano TrozziErica NovoNadia PaneraCristiano De StefanisValentina D'OriaMarco MarzioniLuca MaroniMaurizio ParolaAnna AlisiGianluca Svegliati-BaroniPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Intestinal activation of LXRα modulates hepatic response to injury by increasing circulating HDL levels and SRB1 expression in the liver, thus suggesting this circuit as potential actionable pathway for therapy.