Short-term efficacy of umbilical cord milking in preterm infants: systematic review and meta-analysis.
Joshuan J BarbozaLeonardo Albitres-FloresMarco Rivera-MezaJaime Rodriguez-HuapayaJosé Caballero-AlvaradoVinay PasupuletiAdrian V HernandezPublished in: Pediatric research (2020)
In 14 randomized controlled trials (RCTs), umbilical cord milking (UCM) did not reduce mortality, intraventricular hemorrhage, or patent ductus arteriosus compared to immediate (ICC) or delayed cord clamping (DCC). UCM improved mean blood pressure and hemoglobin levels compared to ICC or DCC. In comparison to ICC, UCM reduced the need for blood transfusion. We updated searches until February 2020, stratified by type of control, and performed subgroup analyses. There was low quality of evidence about clinical efficacy of UCM. Most of RCTs had low risk of bias. UCM cannot be recommended as standard of care for preterm infants.
Keyphrases
- umbilical cord
- preterm infants
- mesenchymal stem cells
- low birth weight
- blood pressure
- randomized controlled trial
- healthcare
- palliative care
- quality improvement
- bone marrow
- cardiovascular events
- clinical trial
- pain management
- systematic review
- coronary artery disease
- type diabetes
- skeletal muscle
- blood glucose
- health insurance