PNPLA3 I148M gene variant and chronic kidney disease in type 2 diabetic patients with NAFLD: Clinical and experimental findings.

Alessandro MantovaniAlice TalientoChiara ZusiGuido BaselliDaniele PratiSimona GranataGianluigi ZazaAntonio ColecchiaClaudio MaffeisChristopher D ByrneLuca Vittorio Valenti Giovanni Targher

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

The PNPLA3 I148M variant was associated with CKD, independently of common renal risk factors and severity of NAFLD PNPLA3 expression levels were particularly high in renal podocytes.

Keyphrases

chronic kidney disease
risk factors
end stage renal disease
poor prognosis
copy number
binding protein
gene expression
diabetic nephropathy
peritoneal dialysis