FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma.

Jiao Huang Wai Ying Tsang Xiao-Na Fang Yu Zhang Jie Luo Lan-Qi Gong Bai-Feng Zhang Ching Ngar Wong Zhi-Hong Li Bei-Lei Liu Jin-Lin Huang Yu-Ma Yang Shan Liu Liu-Xian Ban Yiu Hong Chan Xin-Yuan Guan

Published in: Cancer research (2024)

Inhibition of FASN increases MHC-I protein levels by suppressing its palmitoylation and lysosomal degradation, which stimulates immune activity against hepatocellular carcinoma and enhances the efficacy of immune checkpoint inhibition.

Keyphrases

oxidative stress
small molecule
amino acid
protein protein