Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma.

Simon AndreasenSarah L von HolsteinPreben HomøeSteffen Heegaard

Published in: Acta ophthalmologica (2018)

Rearrangement of PLAG1 and HMGA2 and expression of the corresponding proteins are frequent and specific findings in lacrimal gland PA and ca-ex-PA. The mechanism for PLAG1 overexpression in FISH-negative PAs is yet to be clarified.

Keyphrases

poor prognosis
cell proliferation
genome wide
transcription factor
binding protein
gene expression
dna methylation
genome wide analysis