Human osteoarthritic articular cartilage stem cells suppress osteoclasts and improve subchondral bone remodeling in experimental knee osteoarthritis partially by releasing TNFAIP3.

Zhi-Ling LiXiao-Tong LiRui-Cong HaoFei-Yan WangYu-Xing WangZhi-Dong ZhaoPei-Lin LiBo-Feng YinNing MaoLi DingHeng Zhu

Published in: Stem cell research & therapy (2023)

In summary, we have reported an easy and reproducible human ACSC isolation strategy and revealed their effects on subchondral bone remodeling in OA rats by releasing TNFAIP3 and suppressing osteoclasts in a diseased microenvironment responsive manner.

Keyphrases

knee osteoarthritis
stem cells
endothelial cells
bone loss
bone mineral density
induced pluripotent stem cells
pluripotent stem cells
soft tissue
single cell
cancer therapy
postmenopausal women
drug delivery
cell therapy
bone marrow