Iron metabolism gene expression and prognostic features of hepatocellular carcinoma.
Ying ShenXin LiBin ZhaoYanru XueShenghang WangXin ChenJiancheng YangHuanhuan LvPeng ShangPublished in: Journal of cellular biochemistry (2018)
Iron metabolism is crucial to hepatocellular carcinoma progression and is a key determinant of prognosis. Protein-protein interactions within the iron metabolism gene network were analyzed using the European Molecular Biology Laboratory's Search Tool for Recurring Instances of Neighbouring Genes/Proteins database. We obtained 423 liver hepatocellular carcinoma gene expression profiles from the Cancer Genome Atlas database. The expression and pathway enrichment of representative iron intake genes (TFRC and DMT1), utilization genes (FTH1, FTL, HIF1A, HMOX1, SLC25A37, and SLC25A38), and efflux genes (FLVCR1 and SLC40A1) was investigated in tumor and adjacent tissues. We determined the relationship between iron metabolism and the prognostic features of liver hepatocellular carcinoma. The liver metabolism genes TFRC and FLVCR1 were related to survival, disease status, and prognosis in patients with hepatocellular carcinoma. Our results provide novel insight into liver cancer therapy.
Keyphrases
- genome wide
- genome wide identification
- gene expression
- dna methylation
- genome wide analysis
- cancer therapy
- bioinformatics analysis
- iron deficiency
- copy number
- transcription factor
- young adults
- endothelial cells
- papillary thyroid
- cross sectional
- physical activity
- atomic force microscopy
- weight gain
- single molecule
- drug induced