Farnesoid X Receptor (FXR) Regulates mTORC1 Signaling and Autophagy by Inhibiting SESN2 Expression.

GuoYan WangLei ChenSenLin QinHuiJun GengChao XiaYiNing ZhengXinJian LeiJun ZhangShengRu WuJunHu YaoLu Deng

Published in: Molecular nutrition & food research (2023)

These results indicate that FXR-induced decrease in SESN2 expression and activation of the mTORC1 pathway can control autophagy and be explored as potential therapeutic targets for enterohepatic and metabolic disorders.

Keyphrases

poor prognosis
signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
binding protein
diabetic rats
high glucose
endothelial cells
risk assessment
human health
climate change