Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis.
Fumihiro HirataKohei IshiyamaYuka TanakaTsuyoshi KobayashiMasakazu HashimotoYoshihiro SaekiNobuki IshidaKazuhiro TaguchiJunko TanakaKoji ArihiroHideki Ohdannull nullPublished in: Annals of gastroenterological surgery (2018)
Colorectal cancer with liver metastasis patients treated with neoadjuvant chemotherapy showed enhanced expression of activation markers on peripheral blood and liver NK cells in comparison with patients who did not receive therapy; however, the difference in those function remains unclear. These results suggest that neoadjuvant chemotherapy does not have a negative impact on intrahepatic immune cells in resectable CRLM patients.
Keyphrases
- neoadjuvant chemotherapy
- locally advanced
- rectal cancer
- nk cells
- squamous cell carcinoma
- radiation therapy
- peripheral blood
- sentinel lymph node
- lymph node
- end stage renal disease
- ejection fraction
- newly diagnosed
- poor prognosis
- stem cells
- patient reported outcomes
- bone marrow
- replacement therapy
- patient reported
- chemotherapy induced